Manager, Value, Access & HEOR - Neuroscience / Neuro-Rare Diseases

Position Summary

The Manager, Value, Access & HEOR (Neuroscience / Neuro-Rare) is responsible for developing and executing evidence-based value strategies to secure optimal pricing, reimbursement, and sustainable access for innovative therapies in neurology and rare neurological diseases.

This role leads the development of health economic and outcomes evidence tailored to high unmet need, small patient populations, complex disease burden, and evolving payer frameworks. The position requires strong expertise in neuro specialty and neuro rare disease value demonstration, uncertainty management, and stakeholder engagement with HTA bodies, payers, clinical KOLs, and patient advocacy groups.

Key Responsibilities

1. Neuro-Focused Value & Access Strategy

• Develop and execute integrated value strategies for neuroscience and neuro-rare portfolios
• Shape early access and launch readiness plans considering high unmet need and orphan frameworks
• Lead pricing and reimbursement submissions, including orphan drug positioning
• Support innovative payment solution design
• Monitor evolving neuroscience reimbursement policies and rare disease access pathways

2. HEOR & Evidence Generation (Neuro-Specific)

• Lead development/adaptation of cost-effectiveness and budget impact models reflecting:
• High disability burden
• Long-term neurological sequelae
• Productivity loss and caregiver burden
• Comorbidity risks (e.g., depression, cardiovascular risk in migraine, SUDEP in epilepsy)
• Develop burden of disease evidence demonstrating:
• Quality-of-life impairment
• Indirect economic burden
• Societal impact
• Support RWE strategy, including registry-based evidence and post-launch effectiveness studies
• Address clinical uncertainty typical in rare diseases (small sample sizes, single-arm trials, surrogate endpoints)
• Collaborate with global HEOR teams to localize global value dossiers

3. HTA & Stakeholder Engagement in Neuro/Rare

• Prepare and lead HTA submissions tailored to neurology and rare disease evaluation frameworks
• Translate complex neurological clinical data into payer-relevant value arguments
• Proactively engage clients on unmet need, disease severity, and societal impact
• Support negotiation strategy with scenario modelling and access impact simulations

4. Cross-Functional & External Collaboration

• Partner closely with Medical Affairs, Regulatory, Commercial, and Global HEOR teams
• Work with clinical KOLs in neurology and rare disease networks
• Engage patient advocacy groups to understand patient-relevant outcomes
• Contribute to scientific publications and congress submissions related to HEOR evidence

5. Compliance & Governance

• Ensure all HEOR and access activities comply with regulatory and ethical standards
• Maintain scientific integrity in all submissions and external communications

Qualifications & Experience

Education

• Advanced degree (Master’s/PhD) in Health Economics, Epidemiology, Public Health, Pharmacy, Health Policy, or related discipline

Experience

• 5+ years in Market Access / HEOR / Pricing & Reimbursement
• Experience in neuroscience and/or rare diseases strongly preferred
• Demonstrated experience with HTA submissions in high unmet need or orphan settings
• Experience handling uncertainty and evidence gaps typical in rare disease launches

Technical Skills

• Strong expertise in cost-effectiveness analysis and budget impact modelling
• Understanding of orphan drug policy frameworks and rare disease access pathways
• Experience with RWE design and interpretation from economic part
• Ability to quantify indirect costs and caregiver burden
• Knowledge of neurology disease landscape and treatment pathways

Core Competencies

• Strategic and innovative thinking in complex access environments
• Ability to articulate value beyond traditional cost-effectiveness thresholds
• Strong stakeholder engagement and negotiation support capability
• High analytical rigor with practical business orientation
• Cross-functional leadership and matrix collaboration

Key Success Indicators

• Successful reimbursement of neuro and rare disease products
• High-quality HTA submissions addressing uncertainty effectively
• Evidence package demonstrating societal and long-term value
• Strong stakeholder relationships and access sustainability
• Contribution to lifecycle value optimization