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Principal Scientist

 
Requistion ID:  1144
Location: 

Copenhagen, N/A, DK

Date: 
 

Senior/Principal Scientist within biotransformation/metabolism – Translational DMPK

 

Description

We are looking for an experienced and enthusiastic ADME/DMPK scientist with a proven track record in the field of small molecule in vitro ADME to join the department of Translational DMPK. The department is a key component of the Research organization where we interact closely with other functions such as medicinal and computational chemistry, pharmacology and toxicology to discover and optimize new molecules for CNS diseases. The department is thus fully integrated in the drug discovery process supporting optimization of the DMPK properties of both small and large molecules from early target validation studies through Lead Optimization to selection, profiling and risk assessment of clinical drug candidates.

 

Your job and key responsibilities

Main responsibilities will include provision of DMPK input and guidance to drug discovery programs as DMPK representative sitting within multi-disciplinary drug discovery project teams. The role of the DMPK representative is to interpret and guide research design teams on key aspects of in vitro ADME and pharmacokinetic properties including drug metabolism, metabolite structure elucidation and drug-drug interaction assessment. Further to this, you will be involved in adapting and executing the department strategy within the area of biotransformation/metabolism to meet the evolving needs of the discovery projects. The department is continuously looking to refine and expand our assay platform and capabilities to increase the mechanistic ADME understanding and translation to humans of small molecule drug leads. As a senior/principal scientist you will specifically be involved in maximizing our capabilities within the areas of CYP/non-CYP metabolism, metabolite structure elucidation, metabolic soft-spot identification, reactive metabolite identification/risk assessment and drug-drug interactions.

 

We offer

Lundbeck is a global pharmaceutical company with approximately 5,000 employees specialized in psychiatric and neurological disorders. At Lundbeck we are highly committed to improving the quality of life of people living with brain disease. Translational DMPK is part of the Division of Molecular Discovery and Innovation within Lundbeck Research. The department consists of a mix of 16 skilled scientists, technicians and PhD students and is based at Lundbeck’s headquarters in Valby, Copenhagen. Research studies and assays are conducted inhouse in modern DMPK and bioanalysis laboratories as well as at specialized CRO’s around the world. This is a great opportunity to join a research team dedicated to optimizing the DMPK properties and building the understanding of translation to humans for new molecules targeting CNS diseases.

 

Qualifications

Our preferred candidate is a scientist with comprehensive experience in mechanistic ADME in the field of small molecule biotransformation and metabolism. Further, we are looking for a candidate with the following profile:

  • PhD in relevant subject plus experience in the field of ADME/DMPK, either in pharmaceutical industry or academia
  • Experience as DMPK project representative and strategic awareness and understanding of the role of DMPK in Research & Development
  • Expertise and profound scientific interest within one or more of the following mechanistic ADME disciplines: Metabolism pathways, metabolite identification, reactive metabolites, drug-drug interactions, transporters
  • Good understanding of organic chemistry principles/structural elucidation of small molecules and knowledgeable within structure-properties relationship (SPR) within ADME is highly desirable
  • Experience in interpreting mass spectral (LC-MS/MS) data and other structural elucidation techniques
  • Enjoys working in internal and cross-functional teams and a desire to work in a fast paced, flexible and dynamic discovery environment

 

Your application

Applications should be received no later than August 22nd, 2020 by using the link below and should include a cover letter with curriculum vitae. Names and contact details for one or two referees are welcomed. For further information please contact Christoffer Bundgaard, Senior Manager and Head of Translational DMPK on CHBG@lundbeck.com or +45 30 83 57 85.

Lundbeck is a global pharmaceutical company specialized in brain diseases. For more than 70 years, we have been at the forefront of neuroscience research. We are tirelessly dedicated to restoring brain health, so every person can be their best.


An estimated 700 million people worldwide are living with brain diseases and far too many suffer due to inadequate treatment, discrimination, a reduced number of working days, early retirement and other unnecessary consequences. Every day, we strive for improved treatment and a better life for people living with brain diseases – we call this Progress in Mind.

Read more at www.lundbeck.com/global/about-us/progress-in-mind.
Our approximately 5,000 employees in more than 50 countries are engaged in the entire value chain throughout research, development, production, marketing and sales. Our pipeline consists of several late-stage development programs and our products are available in more than 100 countries. Our research center is based in Denmark and our production facilities are located in Denmark, France and Italy. Lundbeck generated revenue of DKK 18.1 billion in 2018 (EUR 2.4 billion; USD 2.8 billion).

For additional information, we encourage you to visit our corporate site www.lundbeck.com and connect with us on Twitter at @Lundbeck and via LinkedIn.