Senior Scientist, Translational DMPK

Senior Scientist, Translational DMPK

Do you think solving DMPK challenges in drug discovery projects to optimize molecules to become the drugs of the future for brain diseases sound interesting? Let’s do it then - together.

You have the possibility to join our team in Translational Drug Metabolism and Pharmacokinetics (DMPK) as Senior Scientist to contribute to our drug discovery portfolio within small and large molecule projects.

Your new role

• You will be responsible for designing, overseeing, and interpreting screening and mechanistic in vivo pharmacokinetic (PK) assays including blood-brain barrier studies in pre-clinical species.

• You will serve as DMPK project representative to guide research design teams on key aspects of in vitro and in vivo DMPK to support molecule optimization of the drug-like properties and predicted human PK and PK/PD properties.

• In your role you will be interacting closely with cross-functional teams within Medicinal chemistry and biology departments to contribute to the progression of our research projects.

• You will work together with other DMPK scientists and technicians in the department to solve DMPK challenges by integrating in vitro and in vivo data with translational DMPK modelling.

• As Senior Scientist in Translational DMPK you will have the opportunity to apply your scientific skills and ideas to drive, design and implement hypothesis driven studies to answer DMPK or PK/PD questions and further develop our assay platform to increase the DMPK understanding of new molecular entities.

• If you like working in an exploratory research environment where ideas can be tested immediately this is a great opportunity to further develop your scientific career.

Your future team

• Translational DMPK is a key component of the Global Research Organization involved in the drug discovery process supporting optimization of the DMPK and PK/PD properties of both small and large molecules from early target validation studies through lead optimization to selection of clinical drug candidates.

• You will join a team of 15 colleagues in a mix of scientists, technicians, and students in our modern lab and office facilities. Our culture is characterized by openness and purpose driven experimentation in a non-regulated explorative research environment.

• DMPK research studies and assays are conducted inhouse in modern DMPK and bioanalysis laboratories as well as at specialized CRO’s around the world set up to rapidly deliver data to answer key DMPK questions. This is a great opportunity to join a research team dedicated to optimizing the DMPK properties and building the understanding of translation to humans for new molecules targeting CNS diseases.

The position is based in the Lundbeck headquarters in Copenhagen, Denmark.

What you bring to the team

Our preferred candidate is a scientist with experience in the in vivo DMPK field of small molecule or large molecules. Further, we are looking for a candidate with the following profile:

• PhD in relevant life science area and experience in the field of ADME/DMPK or PK/PD either in the pharmaceutical industry or academia.

• Experience in analyzing, interpreting, and translating pharmacokinetic data of small molecules and/or mAbs.

• Knowledge within PK or PBPK modelling software such as Phoenix WinNonlin and GastroPlus.

• Keen interest and knowledgeable within specific areas related to ADME/DMPK such as oral absorption, drug delivery, metabolism, blood-brain barrier penetration, PK or PK/PD analysis.

• An understanding of the role of DMPK and early PK/PD in drug discovery.

• Enjoys working in internal and cross-functional teams and a desire to work in a fast paced, flexible, and dynamic discovery environment.

• License to design and act as study director for animal experiments is beneficial.

Our promise to you  

Lundbeck offers an inspiring workplace and innovative culture, where our curiosity, accountability and adaptability enable us to transform lives. We want to go faster and further on addressing the big unmet needs of people living with brain disorders. We offer rewarding careers with a mix of exciting tasks and development opportunities that are balanced with initiatives focused on your well-being.

We need every brain in the game, and at Lundbeck, we are committed to building a workforce that is as diverse as the people we serve. Read more about our commitment at www.lundbeck.com/global/about-us/our-commitment/diversity-and-inclusion.

Apply now

Can you see yourself in this role? We want to hear from you. Does this sound like your dream job, but you’re not sure if you meet all the requirements? We still want to hear from you!

Upload your CV and include a few lines about your motivation for applying. We ask you not to include a photo or personal information that does not relate to your professional experience.

If you have questions, please contact Christoffer Bundgaard, Director at CHBG@lundbeck.com or +45 30835785.

Applications must be received by March 17, 2025.

Learn more about us at www.lundbeck.com, LinkedIn or Instagram (@h_lundbeck).

#EveryBrainInTheGame

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